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  2. Ketogenesis - Wikipedia

    en.wikipedia.org/wiki/Ketogenesis

    Deaminated amino acids that are ketogenic, such as leucine, also feed TCA cycle, forming acetoacetate & ACoA and thereby produce ketones. [1] Besides its role in the synthesis of ketone bodies, HMG-CoA is also an intermediate in the synthesis of cholesterol, but the steps are compartmentalised. [1] [2] Ketogenesis occurs in the mitochondria ...

  3. 3-Hydroxy-3-methylglutaryl-CoA lyase - Wikipedia

    en.wikipedia.org/wiki/3-hydroxy-3-methylglutaryl...

    3-Hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme (EC 4.1.3.4 that in human is encoded by the HMGCL gene located on chromosome 1. It is a key enzyme in ketogenesis (ketone body formation). It is a ketogenic enzyme in the liver that catalyzes the formation of acetoacetate from HMG-CoA within the mitochondria.

  4. Ketone bodies - Wikipedia

    en.wikipedia.org/wiki/Ketone_bodies

    Ketone bodies are water-soluble molecules or compounds that contain the ketone groups produced from fatty acids by the liver (ketogenesis). [1] [2] Ketone bodies are readily transported into tissues outside the liver, where they are converted into acetyl-CoA (acetyl-Coenzyme A) – which then enters the citric acid cycle (Krebs cycle) and is oxidized for energy.

  5. Hydroxymethylglutaryl-CoA synthase - Wikipedia

    en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA...

    In biochemistry, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway.

  6. Fatty acid metabolism - Wikipedia

    en.wikipedia.org/wiki/Fatty_acid_metabolism

    The ketones are released by the liver into the blood. All cells with mitochondria can take up ketones from the blood and reconvert them into acetyl-CoA, which can then be used as fuel in their citric acid cycles, as no other tissue can divert its oxaloacetate into the gluconeogenic pathway in the way that this can occur in the liver.

  7. HMGCS2 - Wikipedia

    en.wikipedia.org/wiki/HMGCS2

    15360 Ensembl ENSG00000134240 ENSMUSG00000027875 UniProt P54868 P54869 RefSeq (mRNA) NM_001166107 NM_005518 NM_008256 RefSeq (protein) NP_001159579 NP_005509 NP_032282 Location (UCSC) Chr 1: 119.75 – 119.77 Mb Chr 3: 98.19 – 98.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) is an enzyme in humans that is encoded by the ...

  8. Acetoacetyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acetoacetyl-CoA

    Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis. It also takes a similar role in the ketone bodies synthesis (ketogenesis) pathway of the liver. [1] In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a ...

  9. Thiolase - Wikipedia

    en.wikipedia.org/wiki/Thiolase

    Thiolases are a family of evolutionarily related enzymes.Two different types of thiolase [4] [5] [6] are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC 2.3.1.9) and 3-ketoacyl-CoA thiolase (EC 2.3.1.16). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid ...