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Stereocilia (or stereovilli or villi) are non-motile apical cell modifications. They are distinct from cilia and microvilli , but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal cell membrane characteristics.
Resembling hair-like projections, the stereocilia are arranged in bundles of 30–300. [3] Within the bundles the stereocilia are often lined up in several rows of increasing height, similar to a staircase. At the core of these hair-like stereocilia are rigid cross-linked actin filaments, which can renew every
The hair cells have a hair bundle at the apical surface of the cell. The hair bundle consists of an array of actin-based stereocilia. Each stereocilium inserts as a rootlet into a dense filamentous actin mesh known as the cuticular plate. Disruption of these bundles results in hearing impairments and balance defects.
Each hair cell of a macula has 40 to 70 stereocilia and one true cilium called a kinocilium. The stereocilia are oriented by the striola, a curved ridge that runs through the middle of the macula; in the saccule they are oriented away from the striola [2] The tips of the stereocilia and kinocilium are embedded in a gelatinous otolithic membrane ...
161497 140476 Ensembl ENSG00000242866 ENSMUSG00000033498 UniProt Q7RTU9 Q8VIM6 RefSeq (mRNA) NM_153700 NM_080459 RefSeq (protein) NP_714544 NP_536707 Location (UCSC) Chr 15: 43.6 – 43.62 Mb Chr 2: 121.19 – 121.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stereocilin is a protein that in humans is encoded by the STRC gene. The STRC gene provides instructions for creating a ...
The stereocilia atop the IHCs move with this fluid displacement and in response their cation, or positive ion selective, channels are pulled open by cadherin structures called tip links that connect adjacent stereocilia. [9] The organ of Corti, surrounded in potassium-rich fluid endolymph, lies on the basilar membrane at the base of the scala ...
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These otoconia add to the weight and inertia of the membrane and enhance the sense of gravity and motion. With the head erect, the otolithic membrane bears directly down on the hair cells and stimulation is minimal. However, when the head is tilted, the otolithic membrane sags and bends the stereocilia, stimulating the hair cells.