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Labetalol Pregnancy Warnings. AU: Contraindicated during the first trimester of pregnancy. AU (second and third trimester), UK, US: This drug should be used during pregnancy only if the benefit outweighs the risk. AU TGA pregnancy category: C. US FDA pregnancy category: C.
• Medical treatment of chronic hypertension in pregnancy, that is, hypertension present before 20 weeks' gestation, is recommended at 160 mm Hg systolic or 110 mm Hg diastolic with labetalol or...
The drugs most commonly used—methyldopa, labetalol, and nifedipine—are widely accepted as safe in pregnancy, based on many years of experience, observational data from large databases, and meta‐analyses of multiple small clinical trials.
This sheet is about exposure to labetalol in pregnancy and while breastfeeding. This information should not take the place of medical care and advice from your healthcare provider.
Labetalol is a nonselective α, β-1, and β-2 receptor blocker that is used as first line for both acute and chronic hypertension in pregnancy. Dose adjustment along the course of the pregnancy may be required due to increasing clearance leading to a shorter half-life (110) .
Research shows that taking labetalol during pregnancy can lower the risk of heart and kidney problems. It may also lower the risk of preterm birth and low birth weight for your baby. Common labetalol side effects include dizziness, fatigue, and slowed heart rate.
Labetalol (Trandate®) is used to treat high blood pressure (hypertension). Benefits. Risks. Alternatives. No treatment. Will my baby need extra monitoring? You will be offered a detailed scan at around 20 weeks of pregnancy as part of your routine antenatal care.
The study describes pregnancy outcomes, between methyldopa-treated and labetalol-treated women according to a target of “less tight” versus “tight” control of hypertension in pregnancy.
The risk of congenital malformations associated with exposure to β-blockers early in pregnancy: a meta-analysis. Hypertension (Dallas, Tex.: 1979), 62 (2), 375–381. Yang, X. et al. 2019. Distinct outcomes of labetalol exposed infants: case reports and systematic review.
Dosing information. Start with a dose of 100mg labetalol twice a day. Increase the dose at fortnightly intervals if needed and tolerated. Usual dose 200 mg twice daily, increased if necessary up to 800 mg daily in 2 divided doses, to be taken with food, higher doses to be given in 3–4 divided doses.