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Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25 (OH)D3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. [3][4][5] Calcifediol can be further hydroxylated by the enzyme 25 (OH)D-1α-hydroxylase ...
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [1][7][2] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: <12 ng/mL = <30 nmol/L[2] Deficiency ...
A diet insufficient in vitamin D, combined with inadequate sunlight exposure, can lead to vitamin D deficiency, which is defined as a blood 25-hydroxyvitamin D or 25(OH)D level below 12 ng/mL (30 nmol/liter). Vitamin D insufficiency, on the other hand, is characterized by a blood 25(OH)D level between 12–20 ng/mL (30–50 nmol/liter).
24,25-Dihydroxycholecalciferol, also known as 24,25-dihydroxyvitamin D3 and (24R)-hydroxycalcidiol (abbreviated as 24 (R),25- (OH)2D3), [1] is a compound which is closely related to 1,25-dihydroxyvitamin D 3, the active form of vitamin D 3. Like vitamin D 3 itself and calcifediol (25-hydroxyvitamin D 3), it is inactive as a hormone both in ...
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8][9][10] It is also known as 1,25-dihydroxycholecalciferol. It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Michael F. Holick (/ ˈhɒlɪk / HOLL-ik; [1] born 1946) is an American adult endocrinologist, specializing in vitamin D, such as the identification of both calcidiol, the major circulating form of vitamin D, and calcitriol, the active form of vitamin D. His work has been the basis for diagnostic tests and therapies for vitamin D-related diseases.
In a study by Mithal et al., [38] vitamin D insufficiency of various countries was measured by lower 25-hydroxyvitamin D. 25(OH) D is an indicator of vitamin D insufficiency that can be easily measured. These percentages should be regarded as relative vitamin D levels, and not as predicting evidence for development of rickets.