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[6] [5] Fluconazole is in the azole antifungal family of medication. [5] It is believed to work by affecting the fungal cellular membrane. [5] Fluconazole was patented in 1981 and came into commercial use in 1988. [7] It is on the World Health Organization's List of Essential Medicines. [8] Fluconazole is available as a generic medication. [5]
Suspected cases of esophageal candidiasis should be treated with short-term fluconazole antifungal therapy. When symptoms recover after therapy, we can diagnosis esophageal candidiasis and do not need more investigations. [3] Oral fluconazole is most commonly used medication for esophageal candididasis.
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Very rarely Stevens–Johnson syndrome, liver damage, severe allergy has been reported [17] May lower blood sugar excessively in combination with diabetes medication. [17] Contains a chemical linked to possible birth defects. [17]
Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, chronic liver failure or chronic hepatic failure and end-stage liver disease, is an acute condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue and regenerative nodules as a result of chronic liver disease.
Fluconazole is the preferred medication for coccidioidal meningitis, due to its penetration into CSF. [3] Intrathecal or intraventricular amphotericin B therapy is used if infection persists after fluconazole treatment. [31] Itraconazole is used for cases that involve treatment of infected person's bones and joints.
Some possible medications used for visceral disease include liposomal amphotericin B, [9] a combination of pentavalent antimonials and paromomycin, [9] and miltefosine. [10] For cutaneous disease, paromomycin, fluconazole, or pentamidine may be effective. [11] About 4 to 12 million people are currently infected [4] [5] in some 98 countries. [3]
Drugs and drug candidates in this class are fungicidal against some yeasts (most species of Candida, but not Cryptococcus, Trichosporon, and Rhodotorula). Echinocandins also have displayed activity against Candida biofilms, especially in synergistic activity with amphotericin B and additive activity with fluconazole.