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Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The goal of tuberculosis elimination is hampered by the lack of rapid testing, short and effective treatment courses, and completely effective vaccine. [2] The WHO as well as the Stop TB Partnership aim for the full elimination of TB by 2050—requiring a 1000-fold reduction in tuberculosis incidence. [3]
Progression from TB infection to overt TB disease occurs when the bacilli overcome the immune system defenses and begin to multiply. In primary TB disease (some 1–5% of cases), this occurs soon after the initial infection. [13] However, in the majority of cases, a latent infection occurs with no obvious symptoms. [13]
Indonesia plans to run clinical trials of several vaccines to fight surging cases of tuberculosis (TB) this year, with concerns the disease might affect economic growth, ministers said on Monday.
The history of tuberculosis encompasses the origins of the disease, tuberculosis (TB) through to the vaccines and treatments methods developed to contain and mitigate its impact. Throughout history, the disease tuberculosis has been variously known as consumption, phthisis, and the White Plague.
Many people thought the solution to that problem had arrived two years ago, on December 14, 2020, when Sandra Lindsay became the first person in the U.S. to get a Covid vaccine outside of a ...
The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin. [10] [11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [9]
Cattle can be vaccinated against TB using the BCG vaccine used to immunise humans. This is not currently done in the UK because the vaccine causes false positives for the current tuberculin test. A new skin test has been developed – Detect Infected among Vaccinated Animals (DIVA) – and phase 1 trials were completed in 2022. [34]