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The first patient was treated using the Edmonton protocol in March 1999. The protocol was first published in the New England Journal of Medicine in July 2000. [1] The NEJM report was exciting for the diabetes field because the seven patients undergoing the Edmonton protocol remained insulin-independent after an average of 12 months. [citation ...
A study from 2005 showed that islet transplantation has progressed to the point that 58% of the people were insulin independent one year after the operation. [3] A review published 2016 reported a 50 – 70% rate of insulin independence after five years, in five studies from leading transplant centers published 2005 – 2012. [4]
Oral methylprednisolone has a moderate distribution into tissue at 1.38L/kg. [39] Methylprednisolone is primarily eliminated by hepatic metabolism and renal excretion of metabolites; with renal excretion of unchanged methylprednisolone at only 1.3–9.2%. [39] Methylprednisolone can be interconverted with methylprednisone. [32]
[3] [4] Methylprednisolone succinate is provided as two different salts when used as a pharmaceutical drug: a sodium salt (methylprednisolone sodium succinate; brand name Solu-Medrol, others) and a hydrogen salt (methylprednisolone hemisuccinate or methylprednisolone hydrogen succinate; brand name Urbason). [3] [4]
Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances and skin conditions.
Subcutaneous infusion, also known as interstitial infusion or hypodermoclysis, is a form of subcutaneous (under the skin) administration of fluids to the body, often saline or glucose solutions. [26] It is the infusion counterpart of subcutaneous injection with a syringe.
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