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Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis. [10]
The threshold for light sensitivity is much higher in infants compared to adults. From birth, the pupils of an infant remain constricted to limit the amount of entering light. In regards to pupil dimensions, newborns' pupils grow from approximately 2.2 mm to an adult length of 3.3 mm. [ 2 ] A one-month-old infant can detect a light threshold ...
The Apgar score is a quick way for health professionals to evaluate the health of all newborns at 1 and 5 minutes after birth and in response to resuscitation. [1] It was originally developed in 1952 by an anesthesiologist at Columbia University, Virginia Apgar, to address the need for a standardized way to evaluate infants shortly after birth.
In pharmacology, the term ceiling effect refers to the property of increasing doses of a given medication to have progressively smaller incremental effect (an example of diminishing returns). Mixed agonist-antagonist opioids , such as nalbuphine , serve as a classic example of the ceiling effect; increasing the dose of a narcotic frequently ...
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Newborns typically lose 7–10% of their birth weight in the first few days, but they usually regain it within two weeks. [17] During the first month, infants grow about 1 to 1.5 inches (2.5 to 3.8 cm) and gain weight at a rate of about 1 ounce (28 g) per day. [17] Resting heart rate is generally between 70 and 190 beats per minute. [18]
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