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Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D 1 receptor partial agonist. [1] Fenoldopam is used as an antihypertensive agent. [ 2 ] It was approved by the Food and Drug Administration (FDA) in September 1997.
Fenoldopam is a selective D 1 receptor partial agonist that does not cross the blood-brain-barrier and is used intravenously in the treatment of hypertension. Dihydrexidine and adrogolide (ABT-431) (a prodrug of A-86929 with improved bioavailability ) are the only selective, centrally active D 1 -like receptor agonists that have been studied ...
The D 1-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. [1] The D 1-like subfamily consists of two G protein–coupled receptors that are coupled to G s and mediate excitatory neurotransmission, of which include D 1 and D 5. [2]
Zelandopam (INN Tooltip International Nonproprietary Name; developmental code names YM-435, MYD-37) is a selective dopamine D 1-like receptor agonist related to fenoldopam which was under development in Japan for the treatment of hypertension and heart failure but was never marketed.
A dopamine agonist is a compound that activates dopamine receptors. There are two families of dopamine receptors, D 1-like and D 2-like.They are all G protein-coupled receptors.
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
A-68930 is a synthetic compound that acts as a selective dopamine receptor D 1 agonist. [1] [2] It is orally active and has antidepressant and anorectic effects in ...
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