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Load path analysis is a technique of mechanical and structural engineering used to determine the path of maximum stress in a non-uniform load-bearing member in response to an applied load. Load path analysis can be used to minimize the material needed in the load-bearing member to support the design load. Load path analysis may be performed ...
Notch signaling is dysregulated in many cancers, and faulty notch signaling is implicated in many diseases, including T-cell acute lymphoblastic leukemia , [4] cerebral autosomal-dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), multiple sclerosis, Tetralogy of Fallot, and Alagille syndrome. Inhibition of notch ...
When deposition is greater than the critical load of a pollutant for a particular location, it is considered a critical load exceedance, meaning the biota are at increased risk of ecological harm. Some components of an ecosystem are more sensitive to deposition than others; therefore, critical loads can be developed for a variety of ecosystem ...
A load at any other point in the cross section is known as an eccentric load. A short column under the action of an axial load will fail by direct compression before it buckles, but a long column loaded in the same manner will fail by springing suddenly outward laterally (buckling) in a bending mode.
Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. [1] A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at ...
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events.Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. [1]
Unlike cracks, crazes can transmit load between their two faces through these fibrils. Crazes typically initiate when applied tensile stress causes microvoids to nucleate at points of high stress concentration within the polymer, such as those created by scratches, flaws, cracks, dust particles, and molecular heterogeneities.
Porosity may take on several forms from interconnected micro-porosity, folds, and inclusions to macro porosity visible on the part surface. The end result of porosity is the creation of a leak path through the walls of a casting that prevents the part from holding pressure.