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A mastocytoma in dogs (or mast cell tumor in dogs) is a neoplasm originating from mast cells in the domestic dog, which occurs mainly in the skin and subcutis. Mastocytoma are not only extremely common in dogs, but also tend to be much more malignant in them than in other animal species.
Dogs rarely show symptoms of hemangiosarcoma until after the tumor ruptures, causing extensive bleeding. Then symptoms can include short-term lethargy, loss of appetite, enlarged abdomen, weakness in the back legs, paled colored tongue and gums, rapid heart rate, and a weak pulse.
Any dog showing symptoms of mastocytosis or with a grade III tumor has a poor prognosis. Dogs of the Boxer breed have a better than average prognosis because of the relatively benign behavior of their mast cell tumors. [10] Multiple tumors that are treated similarly to solitary tumors do not seem to have a worse prognosis. [18]
These tumors can develop on the skin, subcutaneously, or on a blood vessel within an organ and are highly malignant. The tumors are most fatal when they rupture, causing the dog to suffer from severe loss of blood, or hypovolemia. [6] Dogs are one of three mammalian species that are known to suffer from a transmissible cancer. [7]
Overweight female dogs are especially prone to developing these tumors, and most older or overweight dogs have at least one lipoma. [46] [47] In dogs, lipomas usually occur in the trunk or upper limbs. [45] They are also found less commonly in cattle and horses, and rarely in cats and pigs.
Dog with atopic dermatitis, with signs around the eye created by rubbing. Atopy is a hereditary [3] and chronic (lifelong) allergic skin disease. Signs usually begin between 6 months and 3 years of age, with some breeds of dog, such as the golden retriever, showing signs at an earlier age.
Sometimes symptoms are characterized by lymphadenopathy, which involves loss of appetite, weakness, fever, and in rare cases, sepsis. [9] Pemphigus foliaceus is the most common autoimmune skin disease in dogs, making up around one-third of all canine autoimmune disorders. [16] This disease usually affects areas of the ears and face. [9]
Symptoms include incoordination, nystagmus, head tilt, seizures, and depression. [3] Focal – The disease presents as a granuloma, which mimics a tumor. It usually is found in the cerebrum or cerebellopontine angle. [6] Symptoms may be acute or develop slowly over several months and depend on the location of the lesion. [5]
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