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Airway remodelling is a multifaceted process involving multiple airway tissues. These include goblet cell hyperplasia, leading to increased mucus production, and airway smooth muscle hypertrophy (or smooth muscle cell hyperplasia), leading to the release of pro-inflammatory and pro-fibrotic messengers contributing to subepithelial fibrosis.
The most common cause of emphysema is smoking and smoking cessation is mandatory if this incurable disease is to be treated. Prevention of bronchoconstriction by this pathway is vital for people with emphysema and there are several anticholinergic medications that in combination with mucous thinning agents such as Guaifenesin cause significant ...
The mechanisms behind allergic asthma—i.e., asthma resulting from an immune response to inhaled allergens—are the best understood of the causal factors. In both people with asthma and people who are free of the disease, inhaled allergens that find their way to the inner airways are ingested by a type of cell known as antigen-presenting ...
Airway muscular vasculature controls the flow of nutrients to the airways, the temperature of the airways, as well as the clearance of insoluble particles in the airways, which may play an important role in the activity of inhaled bronchodilators, thus affecting airway reactivity and airway tone changes in obstructive lung diseases. [9]
Reactive airway disease (RAD) is an informal label that physicians apply to patients with symptoms similar to those of asthma. [1] An exact definition of the condition does not exist. [ 1 ] [ 2 ] Individuals who are typically labeled as having RAD generally have a history of wheezing, coughing, dyspnea , and production of sputum that may or may ...
Patients treated with Nucala and an inhaled maintenance therapy for up to 104 weeks had a lower annualised rate of moderate or severe exacerbations than those given a placebo, GSK said. COPD ...
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