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Gastrointestinal upset can cause severe discomfort; it is most common when metformin is first administered, or when the dose is increased. [ 76 ] [ 81 ] The discomfort can often be avoided by beginning at a low dose (1.0 to 1.7 g/day) and increasing the dose gradually, but even with low doses, 5% of people may be unable to tolerate metformin.
A diary to track problems can help determine whether treatments are working. [3] Overactive bladder is estimated to occur in 7–27% of men and 9–43% of women. [1] It becomes more common with age. [1] Some studies suggest that the condition is more common in women, especially when associated with loss of bladder control. [1]
Metformin can also cause a vitamin B12 deficiency, which may be linked with anemia. Stopping the medication or starting vitamin B12 supplementation appears to reverse this. Seek medical advice if ...
Doing so can help limit stomach or bowel problems, which are common within the first few weeks of treatment. ... Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an ...
Sulfonylureas are useful only in type 2 diabetes, as they work by stimulating endogenous release of insulin. They work best with patients over 40 years old who have had diabetes mellitus for under ten years. They cannot be used with type 1 diabetes, or diabetes of pregnancy. They can be safely used with metformin or glitazones.
2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.
The complications of diabetes can dramatically impair quality of life and cause long-lasting disability. Overall, complications are far less common and less severe in people with well-controlled blood sugar levels. [3] [4] [5] Some non-modifiable risk factors such as age at diabetes onset, type of diabetes, gender, and genetics may influence risk.
Management of obesity can include lifestyle changes, medications, or surgery. Although many studies have sought effective interventions, there is currently no evidence-based, well-defined, and efficient intervention to prevent obesity. [1] Treatment for obesity often consists of weight loss via healthy nutrition and increasing physical exercise.
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