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Cytochrome P450 oxidases are important enzymes in xenobiotic metabolism.. Xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as drugs and poisons.
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
Glutathione S-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification.
Heavy metal detox, or detoxification, is the removal of toxic heavy metal substances from the body. In conventional medicine, detoxification can also be achieved artificially by techniques such as dialysis and (in a very limited number of cases) chelation therapy. There is a firm scientific base in evidence-based medicine for this treatment. [7]
Some addiction medicine practitioners use the term withdrawal management instead of detoxification. [ 1 ] [ 2 ] A detoxification program for physical dependence does not necessarily address the precedents of addiction , social factors, psychological addiction, or the often-complex behavioral issues that intermingle with addiction.
The Purification Rundown, also known as the Purif [1] or the Hubbard Method, [2] is a pseudoscientific procedure that advocates of Scientology claim is a detoxification program. There is no evidence for its efficacy in detoxification, and significant evidence from clinicians that it is dangerous.
An invariant point is defined as a representation of an invariant system (0 degrees of freedom by Gibbs' phase rule) by a point on a phase diagram. A univariant line thus represents a univariant system with 1 degree of freedom. Two univariant lines can then define a divariant area with 2 degrees of freedom.
Microsomal epoxide hydrolase is a single polypeptide chain composed of 455 amino acids with a molecular weight of 52.96 kilodaltons. It is known that the N-terminal region of the enzyme is responsible for anchoring the protein to the cell membrane, [3] while the C-terminal region of the enzyme contains catalytic residues. [4]
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