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Estradiol-containing birth control pills, which contain 1 to 3 mg/day estradiol or estradiol valerate, have been found to increase sex hormone-binding globulin (SHBG) levels by 1.5-fold. [101] [102] Oral estradiol valerate at 6 mg/day has been found to increase SHBG levels by 2.5- to 3-fold in transgender women.
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Estradiol benzoate/progesterone/lidocaine (Clinomin Forte) [26] Estradiol cypionate/medroxyprogesterone acetate (Cyclofem, Lunelle) [ 18 ] Estrogens and androgens
In July 2023, the USA Food and Drug Administration (FDA) approved the first over-the-counter (OTC) POP birth control pill to be sold without a prescription in the United States. The pill, marketed under the brand name Opill, is once daily 0.075 mg oral norgestrel. [65]
Estradiol/medroxyprogesterone acetate: 1.44 (1.09–1.89)* Estradiol/dydrogesterone ≤1 mg/day E2 >1 mg/day E2: 1.18 (0.98–1.42) 1.12 (0.90–1.40) 1.34 (0.94–1.90) Estradiol/norethisterone ≤1 mg/day E2 >1 mg/day E2: 1.68 (1.57–1.80)* 1.38 (1.23–1.56)* 1.84 (1.69–2.00)* Estradiol/norgestrel or estradiol/drospirenone: 1.42 (1.00–2.03)
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