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Common antacids include aluminum hydroxide/magnesium hydroxide (Maalox) and calcium carbonate (Tums). Histamine H2 blockers and proton pump inhibitors, such as famotidine (Pepcid) and omeprazole (Prilosec), respectively, can also be used to help relieve heartburn, with no known teratogenic effects or congenital malformations. [12]
Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness. [4] Serious side effects may include pneumonia and seizures. [4] [5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended. [1] Famotidine was patented in 1979 and came into medical use in 1985. [6]
Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [1] [9] [10] It is mainly used in the treatment of heartburn and peptic ulcers.
Common side effects include constipation. [3] Serious side effects may include bezoar formation and encephalopathy. [6] Use appears to be safe in pregnancy and breastfeeding. [6] How it works is unclear but is believed to involve binding to the ulcer and protecting it from further damage. [3] [6]
Common side effects include headaches, diarrhea, abdominal pain, and joint pain. [5] [6] More serious side effects may include severe allergic reactions, a type of chronic inflammation known as atrophic gastritis, Clostridioides difficile colitis, low magnesium, and vitamin B12 deficiency. [5] Use in pregnancy appears to be safe. [5]
Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or even gallstones, Dr. Comite says.
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