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  2. Mitotic inhibitor - Wikipedia

    en.wikipedia.org/wiki/Mitotic_inhibitor

    The structure of paclitaxel, a widely used mitotic inhibitor. A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout, and nail fungus. These drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell divides.

  3. Early Mitotic Inhibitor 1 - Wikipedia

    en.wikipedia.org/wiki/Early_Mitotic_Inhibitor_1

    Early Mitotic Inhibitor 1 (EMI1) is an important cell cycle regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome (APC/C) activity. This protein is present in many organisms including Xenopus, Zebrafish, Drosophila (homologous protein: Rca1), and Humans (also often known as F-box only protein ...

  4. Category:Mitotic inhibitors - Wikipedia

    en.wikipedia.org/wiki/Category:Mitotic_inhibitors

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  5. Taxane - Wikipedia

    en.wikipedia.org/wiki/Taxane

    Thus, in essence, taxanes are mitotic inhibitors. In contrast to the taxanes, the vinca alkaloids prevent mitotic spindle formation through inhibition of tubulin polymerization. Both taxanes and vinca alkaloids are, therefore, named spindle poisons or mitosis poisons, but they act in different ways. Taxanes are also thought to be radiosensitizing.

  6. Monomethyl auristatin E - Wikipedia

    en.wikipedia.org/wiki/Monomethyl_auristatin_E

    Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.

  7. Vinca alkaloid - Wikipedia

    en.wikipedia.org/wiki/Vinca_alkaloid

    Vinca alkaloids are used in chemotherapy for cancer. They are a class of cell cycle–specific cytotoxic drugs that work by inhibiting the ability of cancer cells to divide: Acting upon tubulin, they prevent it from forming into microtubules, a necessary component for cellular division. [13]

  8. Wee1 - Wikipedia

    en.wikipedia.org/wiki/Wee1

    The discovery of the Wee1 gene is accredited to Paul Nurse, who first identified it in fission yeast (Schizosaccharomyces pombe) in 1978. In his initial experiments, Nurse demonstrated Wee1 to be a negative regulator of mitosis, such that Wee1+ activity was critical in preventing premature mitosis in Cdc25+ (a mitotic inducer) yeast cells and increased Wee1+ expression could further delay cell ...

  9. Category:Mitosis - Wikipedia

    en.wikipedia.org/wiki/Category:Mitosis

    Mitotic inhibitors (32 P) Pages in category "Mitosis" The following 42 pages are in this category, out of 42 total. This list may not reflect recent changes. ...