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  2. Allosteric regulation - Wikipedia

    en.wikipedia.org/wiki/Allosteric_regulation

    Allosteric regulation of an enzyme. In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.

  3. Allosteric modulator - Wikipedia

    en.wikipedia.org/wiki/Allosteric_modulator

    The site that an allosteric modulator binds to (i.e., an allosteric site) is not the same one to which an endogenous agonist of the receptor would bind (i.e., an orthosteric site). Modulators and agonists can both be called receptor ligands. [2] Allosteric modulators can be 1 of 3 types either: positive, negative or neutral.

  4. Allosteric enzyme - Wikipedia

    en.wikipedia.org/wiki/Allosteric_enzyme

    Allosteric enzymes need not be oligomers as previously thought, [1] and in fact many systems have demonstrated allostery within single enzymes. [2] In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule at a site other than the enzyme's active site.

  5. Activator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Activator_(genetics)

    A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.

  6. Allopregnanolone - Wikipedia

    en.wikipedia.org/wiki/Allopregnanolone

    Allopregnanolone has also been found to act as a positive allosteric modulator of the GABA A-ρ receptor, though the implications of this action are unclear. [ 36 ] [ 37 ] In addition to its actions on GABA receptors, allopregnanolone, like progesterone, is known to be a negative allosteric modulator of nACh receptors , [ 38 ] and also appears ...

  7. Acetyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acetyl-CoA

    This article needs attention from an expert in biochemistry.The specific problem is: Per this talk page: Needs more context about benzoyl-CoA and lactoyl-CoA.Some content needs to be moved to acyl-CoA article to fatty acyl-CoA..

  8. N-Acetylglutamate synthase - Wikipedia

    en.wikipedia.org/wiki/N-Acetylglutamate_synthase

    A simplified reaction mechanism for N-acetylglutamate synthase (NAGS). Two mechanisms for N-acetyltransferase function have been proposed: a two-step, ping-pong mechanism involving transfer of the relevant acetyl group to an activated cysteine residue [10] and a one-step mechanism through direct attack of the amino nitrogen on the carbonyl group. [11]

  9. Binding site - Wikipedia

    en.wikipedia.org/wiki/Binding_site

    [4] [22] The binding of a ligand to an allosteric site of a multimeric enzyme often induces positive cooperativity, that is the binding of one substrate induces a favorable conformation change and increases the enzyme's likelihood to bind to a second substrate. [23]