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Nucleic acid structure prediction; Molecular Modelling; Molecular modeling on GPUs; Molecular graphics; Molecular mechanics; Molecular dynamics; Molecular design software
DNADynamo is a general purpose DNA and Protein sequence analysis package that can carry out most of the functions required by a standard research molecular biology laboratory DNA and Protein Sequence viewing, editing and annotating; Contig assembly and chromatogram editing including comparison to a reference sequence to identify mutations
Orac download page: NAMD + VMD: Yes Yes Yes Yes No Yes I Yes Yes Fast, parallel MD, CUDA Proprietary, free academic use, source code Beckman Institute: NWChem: No No Yes Yes No No Yes No No High-performance computational chemistry software, includes quantum mechanics, molecular dynamics and combined QM-MM methods
Framsticks allows users to design organisms or manually edit the living genetic code of an organism. Users have the ability to seed the environment with energy orbs that the organisms convert to energy and material. Depending on how the organism does in its lifespan determines the future of the virtual gene pool. Gene pools can be exported and ...
Many genetic disorders can be caused by mutation of a single gene. New sequencing techniques however, have shown that a single individual can have up to 3.5 million alterations in the whole genome, most of which do not have a detrimental health effect. [3] The challenge of prediction tools is thus to filter harmless mutations from disease ...
Site-directed mutagenesis is a molecular biology method that is used to make specific and intentional mutating changes to the DNA sequence of a gene and any gene products. Also called site-specific mutagenesis or oligonucleotide-directed mutagenesis , it is used for investigating the structure and biological activity of DNA , RNA , and protein ...
Slipped strand mispairing (SSM, also known as replication slippage) is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases. Slipped strand mispairing is one explanation for the origin and evolution of repetitive DNA sequences. [1]
In the 1980s and 1990s, positional cloning consisted of genetic mapping, physical mapping, and discerning the gene mutation. [11] Discovering disease loci using old forward genetic techniques was a very long and difficult process and much of the work went into mapping and cloning the gene through association studies and chromosome walking.