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MGUS is a relatively stable condition afflicting 3% of people aged 50 and 5% of people aged 70; it progresses to multiple myeloma at a rate of 0.5–1% cases per year; smoldering multiple myeloma does so at a rate of 10% per year for the first 5 years, but then falls off sharply to 3% per year for the next 5 years and thereafter to 1% per year.
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Multiple myeloma cells with higher levels of CD38 show greater daratumumab-mediated cell lysis than cells with low CD38 expression. [28] CD38 enzyme results in the formation of the immunosuppressive substance adenosine , so eliminating CD38-containing cells increases the ability of the immune system to eliminate cancer.
In rare instances, Waldenström macroglobulinemia progresses to multiple myeloma. [78] The International Prognostic Scoring System for Waldenström's Macroglobulinemia is a predictive model to characterise long-term outcomes. [79] [80] According to the model, factors predicting reduced survival [81] are: Age > 65 years; Hemoglobin ≤ 11.5 g/dL
After two decades together, Scialfa was diagnosed with multiple myeloma, a rare form of blood cancer, in 2018. She confirmed her diagnosis in Springsteen’s Rock Diary documentary, which ...
POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. The name POEMS is an acronym for some of the disease's major signs and symptoms ( p olyneuropathy , o rganomegaly , e ndocrinopathy , m yeloma protein , and ...
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