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Oxazolidinones are useful as Evans auxiliaries, which are of interest for chiral synthesis. In a common implementation, an acid chloride substrate reacts with a chiral oxazolidinone to form an imide. Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of the substrate. [6]
The antimicrobial spectrum of an antibiotic can be determined by testing its antimicrobial activity against a wide range of microbes in vitro. Nonetheless, the range of microorganisms which an antibiotic can kill or inhibit in vivo may not always be the same as the antimicrobial spectrum based on data collected in vitro. [2] [5]
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
Bactericidal for both Gram-positive and Gram-negative organisms and therefore useful for empiric broad-spectrum antibacterial coverage. (Notes: MRSA resistance to this class. All are active against Pseudomonas aeruginosa except ertapenem.) Gastrointestinal upset and diarrhea; Nausea; Seizures; Headache; Rash and allergic reactions
A standard APW extinguisher in the United States contains 9.5 litres (2.5 US gal) of water in a stainless steel tank. The water is discharged by means of a 13 mm (1 ⁄ 2 in) hose, with a smooth-bore nozzle attached to the tip. They will initially produce a 12–15 m (40–50 ft) stream of water, with a discharge time of about 50 seconds.
Then, analyte molecules M are protonated by the water cluster ions. Finally, the ionization products MH + (H 2 O) m transfer out from the atmospheric-pressure ion source. Declustering (removal of water molecules from the protonated analyte molecule) of MH + (H 2 O) m takes place at the high vacuum of the mass analyzer. [2]
Chitosan is a nontoxic polymer that has displayed broad-spectrum antimicrobial activity. [12] [1] The mechanism of action for chitosan includes electrostatic interaction, the chelate effect, and the hydrophobic effect. Electrostatic interaction is the primary initial interaction when the pH is lower, while the chelating and hydrophobic effects ...
The UV lamps for water treatment consist of specialized low-pressure mercury-vapor lamps that produce ultraviolet radiation at 254 nm, or medium-pressure UV lamps that produce a polychromatic output from 200 nm to visible and infrared energy. The UV lamp never contacts the water; it is either housed in a quartz glass sleeve inside the water ...