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Oxazolidinones are useful as Evans auxiliaries, which are of interest for chiral synthesis. In a common implementation, an acid chloride substrate reacts with a chiral oxazolidinone to form an imide. Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of the substrate. [6]
The antimicrobial spectrum of an antibiotic can be determined by testing its antimicrobial activity against a wide range of microbes in vitro. Nonetheless, the range of microorganisms which an antibiotic can kill or inhibit in vivo may not always be the same as the antimicrobial spectrum based on data collected in vitro. [2] [5]
The oxazolidinone pharmacophore—the chemical "template" essential for antimicrobial activity—consists of a 1,3-oxazolidin-2-one moiety with an aryl group at position 3 and an S-methyl group, with another substituent attached to it, at position 5 (the R-enantiomers of all oxazolidinones are devoid of antibiotic properties). [108]
A standard APW extinguisher in the United States contains 9.5 litres (2.5 US gal) of water in a stainless steel tank. The water is discharged by means of a 13 mm (1 ⁄ 2 in) hose, with a smooth-bore nozzle attached to the tip. They will initially produce a 12–15 m (40–50 ft) stream of water, with a discharge time of about 50 seconds.
This type of spray nozzle may require more atomizing air and a higher atomizing air pressure drop because the mixing and atomization of liquid takes place outside the nozzle. The liquid pressure drop is lower for this type of nozzle, sometimes drawing liquid into the nozzle due to the suction caused by the atomizing air nozzles (siphon nozzle).
An atomized spray produced from an ultrasonic nozzle is subjected to a heated substrate typically ranging from 300–400 degrees C. [23] Due to the high temperatures of the spray chamber, extensions to the ultrasonic nozzle (as pictured and labeled – High Temperature Ultrasonic Nozzle) [citation needed] such as a removable tip (tip is hidden ...
Air-aspirating nozzles use an opening in the cone shaped nozzle to inject air into a stream of water based foam (CAFS/AFFF/FFFP) to make the concentrate "foam up". Most commonly found on foam extinguishers and foam handlines. Swirl nozzles inject the liquid in tangentially, and it spirals into the center and then exits through the central hole ...
The UV lamps for water treatment consist of specialized low-pressure mercury-vapor lamps that produce ultraviolet radiation at 254 nm, or medium-pressure UV lamps that produce a polychromatic output from 200 nm to visible and infrared energy. The UV lamp never contacts the water; it is either housed in a quartz glass sleeve inside the water ...