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[1] [2] There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene, RORA, RORB, and RORC respectively. The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. [ 3 ]
In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity.
RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene. [5] RORα participates in the transcriptional regulation of some genes involved in circadian rhythm . [ 6 ]
26564 Ensembl ENSG00000169071 ENSMUSG00000021464 UniProt Q01974 Q9Z138 Q8C3W2 RefSeq (mRNA) NM_004560 NM_001318204 NM_013846 RefSeq (protein) NP_001305133 NP_004551 NP_038874 Location (UCSC) Chr 9: 91.56 – 91.95 Mb Chr 13: 53.26 – 53.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase ...
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Plus Codes logo. The Open Location Code (OLC) is a geocode based on a system of regular grids for identifying an area anywhere on the Earth. [1] It was developed at Google's Zürich engineering office, [2] and released late October 2014. [3] Location codes created by the OLC system are referred to as "plus codes".
Weight gain (dose-dependent). Weight gain of over 7% of a person's initial body weight prior to treatment is in this category of very common too with some estimates of its incidence putting it at around 40.6%. This adverse effect is most likely the result of its potent 5-HT 2C receptor and H 1 receptor blockade (or more specifically inverse ...