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CimaVax-EGF is a vaccine used to treat cancer, specifically non-small-cell lung carcinoma (NSCLC). CIMAvax-EGF is composed of recombinant human epidermal growth factor (EGF) conjugated to a protein carrier. [2] The vaccine was developed by the Center of Molecular Immunology, Havana, Cuba, and made available to the Cuban population in 2011.
Cold boxes are typically used to carry vaccines around the area. It is a self-supporting container with insulation and ice-packs surrounding the interior to keep vaccines at low temperatures. [22] Unlike the refrigerator, the cold box has limited time to maintain temperatures below +10 °C, normally 48–96 hours. [23]
That company took the vaccine into Phase III trials in 2004 however these trials were halted in 2008 due to an apparent lack of efficacy. [4] Cell Genesys continued development, however in August 2009, due to funding difficulties, the company announced that it was merging with BioSante Pharmaceuticals . [ 5 ]
A cancer vaccine, or oncovaccine, is a vaccine that either treats existing cancer or prevents development of cancer. [1] Vaccines that treat existing cancer are known as therapeutic cancer vaccines or tumor antigen vaccines. Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient.
To produce viral vaccines, candidate vaccine viruses are grown in mammalian, avian or insect tissue culture of cells with a finite lifespan. [5] These cells are typically Madin-Darby Canine Kidney cells, [6] but others are also used including monkey cell lines pMK and Vero and human cell lines HEK 293, MRC 5, Per.C6, PMK, and WI-38. [7]
The maximum payment per claim is currently £120,000. The 'disability threshold' before payments are granted is 60%. The scheme covers vaccinations for illnesses such as tetanus, measles, tuberculosis, and meningitis C. As of 2005, the British government had paid out £3.5 million to vaccine injury patients since 1997. [43]
Personalized mRNA cancer vaccine therapy is a therapy that uses a personalized cancer vaccine based on mRNA vaccine technology to target existing tumors in patients. As of 2024, number of mRNA cancer vaccines are in clinical trials, of which many are personalized therapies based on engineering mRNA-mediated immune response that targets the patient's particular strain of cancer cells.
The dendritic cell-based cancer vaccine is an innovation in therapeutic strategy for cancer patients. Dendritic cells (DCs) are antigen presenting cells for the induction of antigen specific T cell response. [1] DC-based immunotherapy is safe and can promote antitumor immune responses and prolonged survival of cancer patients. [2]
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