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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. [1] The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma , a monoclonal gammopathy of uncertain significance (MGUS), or further investigate a discrepancy ...
Quantitative proteomics has the largest applications in the protein target identification, protein target validation, and toxicity profiling of drug discovery. [24] Drug discovery has been used to investigate protein-protein interaction and, more recently, drug-small molecule interactions, a field of study called chemoproteomics. Thus, it has ...
Adrenocorticotropic hormone, on the other hand, with a molar mass of 4540, [13] is 0.7 decades to the right in the mass image. Substances with molar mass below 1000g/mol (e.g. electrolytes and metabolites) would have "negative" distance, that is, masses deviating to the left.
Isobaric tags for relative and absolute quantitation (iTRAQ) is an isobaric labeling method used in quantitative proteomics by tandem mass spectrometry to determine the amount of proteins from different sources in a single experiment.
Cystatin C levels have been reported to be altered in patients with cancer, [21] [22] [23] (even subtle) thyroid dysfunction [24] [25] [26] and glucocorticoid therapy in some [27] [28] but not all [29] situations. Other reports have found that levels are influenced by cigarette smoking and levels of C-reactive protein. [30]
The tags contain four regions, namely a mass reporter region (M), a cleavable linker region (F), a mass normalization region (N) and a protein reactive group (R). The chemical structures of all the tags are identical but each contains isotopes substituted at various positions, such that the mass reporter and mass normalization regions have ...
C-reactive protein, an acute phase protein produced by the liver; cAMP receptor protein (catabolite gene activator protein) Cysteine-rich protein, a class of small proteins; Carbon-fiber-reinforced polymers; Chinese restaurant process, in probability theory; Chronic relapsing polyneuropathy, an acquired disorder of the nervous system