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Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [1] [9] [10] It is mainly used in the treatment of heartburn and peptic ulcers. [1] [10] [11]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
2 Adverse effects. 3 History and development. ... Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and ...
Its use, however, is mainly as a second or third line agent, due to side effects such as hypotension, bradycardia, and drowsiness. [42] Clonidine can be administered intrathecally , [ 43 ] which confers various benefits, including a reduction or prevention of the blood pressure lowering effects and increased effectiveness against spasticity. [ 44 ]
And some “may have merit,” Dr. Elizabeth Swenson, an ob-gyn at online health care provider Wisp, tells Yahoo Life, “since natural ingredients like L-arginine have been associated with ...
Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness. [4] Serious side effects may include pneumonia and seizures. [4] [5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended. [1] Famotidine was patented in 1979 and came into medical use in 1985. [6]
Sir James Whyte Black (14 June 1924 – 22 March 2010 [2]) was a Scottish physician and pharmacologist.Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational drug-design, which, in his case, led to the development of propranolol and cimetidine.
The most common side effects of tramadol in order of decreasing incidence are: [1] [2 ... Serious adverse effects are in bold. Very common (>10% frequency) ...
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