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If the pregnancy involves twins, a higher dosage of mifepristone may be recommended. [24] Medical abortion performed very early, before the pregnancy can be detected by ultrasound, is just as safe and effective as medical abortion after the pregnancy is detectable by ultrasound. [25]
Women who miscarry early in their pregnancy usually do not require any subsequent medical treatment but they can benefit from support and counseling. [ 38 ] [ 123 ] Most early miscarriages will be completed on their own; in other cases, medication treatment or aspiration of the products of conception can be used to remove the remaining tissue ...
This weakening is a normal process that typically happens at term as the body prepares for labor and delivery. However, this can be a problem when it occurs before 37 weeks (preterm). The natural weakening of fetal membranes is thought to be due to one or a combination of the following. In PROM, these processes are activated too early: [12]
Mifepristone, and also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy. [8] This combination is 97% effective [9] during the first 63 days (9 weeks) of pregnancy, yet effective in the second trimester as well.
Based on the studies that show that trimethoprim crosses the placenta and can affect folate metabolism, there has been growing evidence of the risk of structural birth defects associated with trimethoprim, especially during the first trimester of pregnancy. [21] The trophoblasts in the early fetus are sensitive to changes in the folate cycle.
While antibiotics can get rid of bacterial vaginosis in pregnancy, this does not appear to change the risk of preterm birth. [115] It has been suggested that chronic chorioamnionitis is not sufficiently treated by antibiotics alone (and therefore they cannot ameliorate the need for preterm delivery in this condition). [95]
The Mercer protocol is a common regimen for antibiotic prophylaxis in the context of preterm premature rupture of membranes (PPROM) during pregnancy, when immediate delivery is contraindicated due to known or suspected fetal lung immaturity.
[38] [39] Together they are effective in around 95% for early pregnancies. [40] Misoprostol alone may be more effective in earlier gestation. [41] Misoprostol can also be used to dilate the cervix in preparation for a surgical abortion, particularly in the second trimester (either alone or in combination with osmotic dilators). [citation needed]