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Cathepsin E is an enzyme (EC 3.4.23.34) that in humans is encoded by the CTSE gene. [5] [6] [7] The enzyme is also known as slow-moving proteinase, erythrocyte membrane aspartic proteinase, SMP, EMAP, non-pepsin proteinase, cathepsin D-like acid proteinase, cathepsin E-like acid proteinase, cathepsin D-type proteinase) is an enzyme.
The catalytic sites of cathepsin D include two critical aspartic residues (amino acid 33 and 231) located on the 14 kDa and 34kDa chains. [11] The ultimate form of mature cathepsin D is composed of 337 amino acid residues, 196 amino acid residues in the heavy chain and 141 in the light chain. These two chains are linked by the hydrophobic ...
[1] [2] Cancer, Cathepsin D is a mitogen and "it attenuates the anti-tumor immune response of decaying chemokines to inhibit the function of dendritic cells". Cathepsins B and L are involved in matrix degradation and cell invasion. [3] Stroke [4] Traumatic brain injury [5] Alzheimer's disease [6] Arthritis [7]
Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. [5] Expression of BACE1 is observed mainly in neurons and oligodendrocytes. [6]
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. [ 3 ] [ 4 ] [ 5 ] The protein is a cysteine cathepsin , a lysosomal cysteine protease that plays a major role in intracellular protein catabolism .
13437 Ensembl ENSG00000123992 ENSMUSG00000026209 UniProt Q9ULA0 Q9Z2W0 RefSeq (mRNA) NM_012100 NM_001319116 NM_001319117 NM_001319118 NM_001319119 NM_001319120 NM_001319121 NM_001319122 NM_001110831 NM_016878 RefSeq (protein) NP_001306045 NP_001306046 NP_001306047 NP_001306048 NP_001306049 NP_001306050 NP_001306051 NP_036232 NP_001306050.1 NP_001306051.1 NP_001104301 NP_058574 Location (UCSC ...
290 16790 Ensembl ENSG00000166825 ENSMUSG00000039062 UniProt P15144 P97449 RefSeq (mRNA) NM_001150 NM_001381923 NM_001381924 NM_008486 RefSeq (protein) NP_001141 NP_001368852 NP_001368853 NP_032512 Location (UCSC) Chr 15: 89.78 – 89.82 Mb Chr 7: 79.47 – 79.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Membrane alanyl aminopeptidase (EC 3.4.11.2) also known as alanyl ...
824 12334 Ensembl ENSG00000162909 ENSMUSG00000026509 UniProt P17655 O08529 RefSeq (mRNA) NM_001146068 NM_001748 NM_009794 RefSeq (protein) NP_001139540 NP_001739 NP_033924 Location (UCSC) Chr 1: 223.7 – 223.78 Mb Chr 1: 182.29 – 182.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene. Function The ...