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Up to 18% of Morpholinos appear to induce nontarget-related phenotypes including cell death in the central nervous system and somite tissues of zebrafish embryos. [43] Most of these effects are due to activation of p53-mediated apoptosis and can be suppressed by co-injection of an anti-p53 Morpholino along with the experimental Morpholino.
This layer functions in protection by allowing the embryo to develop in a hypotonic solution so the cell will not burst. [5] Finally, the third set of blastomeres are the deep cells. These deep cells are located between the enveloping layer and the yolk syncytial layer and eventually give rise to the embryo proper. [1]
The Zebrafish Information Network is an online biological database of information about the zebrafish (Danio rerio). The zebrafish is a widely used model organism for genetic , genomic , and developmental studies, and ZFIN provides an integrated interface for querying and displaying the large volume of data generated by this research. [ 2 ]
The zebrafish (Danio rerio) is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes.Native to South Asia, [3] it is a popular aquarium fish, frequently sold under the trade name zebra danio [4] (and thus often called a "tropical fish" although it is both tropical and subtropical).
Diagram of stages of embryo development to a larval and adult stage. In developmental biology, animal embryonic development, also known as animal embryogenesis, is the developmental stage of an animal embryo. Embryonic development starts with the fertilization of an egg cell (ovum) by a sperm cell (spermatozoon). [1]
12562 Ensembl ENSG00000179776 ENSMUSG00000031871 UniProt P33151 P55284 RefSeq (mRNA) NM_001114117 NM_001795 NM_009868 RefSeq (protein) NP_001786 NP_033998 Location (UCSC) Chr 16: 66.37 – 66.4 Mb Chr 8: 104.83 – 104.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cadherin-5, or VE-cadherin (vascular endothelial cadherin), also known as CD144 (C luster of D ifferentiation 144 ...
This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part ...
In some cases, the vegetal pole is thought to differentiate into the extraembryonic membranes that protect and nourish the developing embryo, such as the placenta in mammals and the chorion in birds. In amphibians, the development of the animal-vegetal axis occurs prior to fertilization. [ 1 ]