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Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene. [5] [6] [7] TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.
Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene. [5] [6] [7]TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.
83433 Ensembl ENSG00000095970 ENSMUSG00000023992 UniProt Q9NZC2 Q99NH8 RefSeq (mRNA) NM_001271821 NM_018965 NM_001272078 NM_031254 RefSeq (protein) NP_001258750 NP_061838 NP_001259007 NP_112544 Location (UCSC) Chr 6: 41.16 – 41.16 Mb Chr 17: 48.65 – 48.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in ...
TREM1, a triggering receptor expressed on myeloid cells 1, a human gene; TREM2, a triggering receptor expressed on myeloid cells 2, a human gene; Trem Desportivo Clube; Trem da Alegria, children musical band in Brazil; Trem das Onze, classical samba composition by Brazilian singer Adoniran Barbosa; Tremulous, a popular free and open source FPS ...
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
V-set domains are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junctional adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in ...
The establishment and maintenance of self-tolerance is an essential property of an immune system designed to eliminate foreign substances. Avoiding self-reactivity in the T cell compartment is maintained by: clonal deletion in the thymus and suppressive cells that eliminate or induce tolerance on autoreactive lymphocytes that escaped selection.
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