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Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung ...
Total body irradiation (TBI) is a radiation therapy technique used to prepare the body to receive a bone marrow transplant. Brachytherapy , in which a radioactive source is placed inside or next to the area requiring treatment, is another form of radiation therapy that minimizes exposure to healthy tissue during procedures to treat cancers of ...
The emetogenic potential of radiotherapy is classified into high, moderate, low and minimal risk depending on the site of irradiation: [5] High risk: total body irradiation (TBI) is associated with a high risk of RINV; Moderate risk: radiation of the upper abdomen, half body irradiation and upper body irradiation
Conditioning regimen: The COG JMML study involves eight rounds of total-body irradiation (TBI) and doses of cyclophosphamide to prepare the JMML child's body for bone marrow transplant. The use of TBI is controversial, though, because of the possibility of late side effects such as slower growth, sterility, learning disabilities, and secondary ...
The treatment of some leukaemias and lymphomas requires the use of high-dose chemotherapy, and total body irradiation (TBI). This treatment ablates the bone marrow, and hence the body's ability to recover and repopulate the blood.
Radiation therapy (or radiotherapy) is used on painful bony areas, in high disease burdens, or as part of the preparations for a bone marrow transplant (total body irradiation). In the past, physicians commonly utilized radiation in the form of whole-brain radiation for central nervous system prophylaxis, to prevent the occurrence and/or ...
Thiotepa is indicated for use in combination with other chemotherapy agents to treat cancer. [5] [7] [9] This can be with or without total body irradiation (TBI), as a conditioning treatment prior to allogeneic or autologous hematopoietic progenitor cell transplantation (HPCT) in hematological diseases in adults and children.
Cobalt-60, produced by neutron irradiation of ordinary cobalt metal in a reactor, is a high activity gamma-ray emitter, emitting 1.17 and 1.33 MeV gamma rays with an activity of 44 TBq/g (1,200 Ci/g). The main reason for its wide use in radiotherapy is that it has a longer half-life, 5.27 years, than many other gamma emitters. However, this ...