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2-Chloromethylpyridine is an organohalide that consists of a pyridine core bearing a chloromethyl group. It is one of three isomeric chloromethylpyridines, along with 3- and 4-chloromethylpyridine. It is an alkylating agent. 2-Chloromethylpyridine is a precursor to pyridine-containing ligands. [1] [2]
In these conversions, chloride is displaced. [2] Pyrithione, the conjugate base of 2-mercaptopyridine-N-oxide, is a fungicide found in some shampoos. Oxidation 2-chloropyridine gives 2-chloropyridine-N-oxide. [5] The antihistamine pheniramine may be generated via the reaction of phenylacetonitrile with 2-chloropyridine in the presence of a base ...
Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine. [1] 2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride. [1]
Structure of the chloromethyl group. In organic chemistry, the chloromethyl group is a functional group that has the chemical formula −CH 2 −Cl. The naming of this group is derived from the methyl group (which has the formula −CH 3), by replacing one hydrogen atom by a chlorine atom. Compounds with this group are a subclass of the ...
Heating the reaction intermediate with 2-chloro-5-(chloromethyl)pyridine in THF under reflux yields flupyradifurone. [2] In the second method, tetronic acid, 4-touluenesulfonic acid, and N -[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethane-1-amine in toluene are heated under reflux for 2 hours to produce flupyradifurone.
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This is the list of extremely hazardous substances defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. § 11002).The list can be found as an appendix to 40 CFR 355. [1]
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