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TLRs are key regulators of both innate and adaptive immune responses. [30] Unlike RelA, RelB, and c-Rel, the p50 and p52 NF-κB subunits do not contain transactivation domains in their C terminal halves. Nevertheless, the p50 and p52 NF-κB members play critical roles in modulating the specificity of NF-κB function.
In the inactive state, RELA/p50 complex is mainly sequestered by IκBα in the cytosol. TNFα, LPS and other factors serve as activation inducers, followed by phosphorylation at residue 32 and 36 of IκBα, leading to rapid degradation of IκBα via the ubiquitin-proteasomal system and subsequent release of RELA/p50 complex. [ 10 ]
P50 (neuroscience), an auditory event-related potential recorded using EEG P50 (pressure) , the partial pressure of a gas required to achieve 50% enzyme saturation ASCC1 , activating signal cointegrator 1 complex subunit 1
The first one to be made was Mazinger Z, and it featured launchable fists and a separate Hover Pilder. Subsequently, mechanical beasts Belgas V5, Brutus M3, Grengus C3 and Gelbros J3 were added to the line. These shared Mazinger's body but with different paint work and the particular traits of each mecha.
Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. [5]This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein.
Centrifugal governors, also known as "centrifugal regulators" and "fly-ball governors", were invented by Christiaan Huygens and used to regulate the distance and pressure between millstones in windmills in the 17th century.
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The handy billy, formally designated "P50", because it pumped 50 gallons per minute, was gasoline-powered and could be used, during flooding conditions, in conjunction with other pumps on the ship. However, it was especially valuable when the ship lost electrical power and normal pumping ability was lost.
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