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Alpha blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). [2] Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system.
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein [5]) that is activated by the sex hormone estrogen.
It was the first alpha blocker which was used for treating Benign Prostatic Hyperplasia. [22] Another Alpha Blocker Prazosin, which was the first drug selective to alpha 1 receptor, was developed in 1987 [22] for the therapy of Benign Prostatic Hyperplasia. Other alpha blockers are then introduced for several diseases. [22]
According to a 2008 review of studies on tadalafil, 15 percent of men who used this medication at its highest recommended dose ... Alpha-blockers. When taken with Cialis, alpha-blockers can cause ...
There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively).Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. [3]
The answer is estrogen. Estrogen , along with progesterone , are hormones associated with sexual and reproductive health in women, promoting the onset of the menstrual cycle, breast development ...
The possibility for selective alpha 2 blockers to interact with non-target receptors, such as 5-HT serotonin receptors, can result in adverse effects, including weight gain and reduced movement due to serotonin receptor antagonism. [1] [9] Alpha 2 blockers are rarely utilised in clinical practice because of their substantial off-target binding ...
2101 26379 Ensembl ENSG00000173153 ENSMUSG00000024955 UniProt P11474 O08580 RefSeq (mRNA) NM_001282450 NM_001282451 NM_004451 NM_007953 RefSeq (protein) NP_001269379 NP_001269380 NP_004442 NP_031979 Location (UCSC) Chr 11: 64.31 – 64.32 Mb Chr 19: 6.89 – 6.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear ...