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STP was first synthesized and tested in 1963 by Alexander Shulgin, who was investigating the effect of 4-position substitutions on psychedelic amphetamines. [3]In mid-1967, tablets containing 20 mg (later 10 mg) of STP were widely distributed in the Haight-Ashbury District of San Francisco under the name of STP, having been manufactured by underground chemists Owsley Stanley and Tim Scully.
Ganesha (2,5-dimethoxy-3,4-dimethylamphetamine) is a lesser-known psychedelic drug.It is also a substituted amphetamine.It was first synthesized by Alexander Shulgin. [citation needed] In his book PiHKAL, the dosage range is listed as 24–32 mg. [1] The drug is usually taken orally, although other routes such as rectally may also be used.
It is much more potent than its positional isomer 3,4,5-trimethoxyamphetamine (3,4,5-TMA, TMA, or TMA-1), which is said to be active at doses of 100 to 250 mg and to have a duration of 6 to 8 hours. [3] However, DOM (2,5-dimethoxy-4-methylamphetamine), the analogue of TMA-2 in which its 4-methoxy group has been replaced with a more lipophilic 4 ...
Like many other psychedelics, aleph is a partial agonist at the 5-HT 2A receptor (EC 50 = 10 nM). [2] It has weak MAO-A inhibitory activity with an IC 50 of 5.2 μM. For reference, amphetamine has an IC 50 of 11 μM and 4-methylthioamphetamine has a value of 0.2 μM. [3] A lower number indicates stronger inhibition.
2C-D (2,5-dimethoxy-4-methylphenethylamine or 2C-M) is a psychedelic drug of the 2C family that is sometimes used as an entheogen. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences, [ 1 ] and its activity was subsequently investigated in humans by Alexander Shulgin .
It is a substituted methamphetamine and a homolog of 2,5-dimethoxy-4-methylamphetamine (DOM). Beatrice was first synthesized by Alexander Shulgin. In his book PiHKAL, the minimum dosage is listed as 30 mg, and the duration listed as 6–10 hours. [1] Beatrice produces a vague feeling of openness and receptiveness, and causes a stimulative effect.
Dimethoxy-4-amylamphetamine (DOAM) is a lesser-known psychedelic drug and a substituted amphetamine. DOAM was first synthesized by Alexander Shulgin . In his book PiHKAL (Phenethylamines i Have Known And Loved) , the minimum dosage is listed as 10 mg, and the duration is unknown.
2,5-Dimethoxy-4-butylamphetamine (DOBU) is a lesser-known psychedelic drug and a substituted amphetamine. DOBU was first synthesized by Alexander Shulgin . In his book PiHKAL (Phenethylamines i Have Known And Loved) , only low dosages of 2–3 mg were tested, with the duration simply listed as "very long".