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  2. Rectal administration - Wikipedia

    en.wikipedia.org/wiki/Rectal_administration

    Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia , ileus , or bowel obstruction , that would interfere with the progression of the medication through the tract.

  3. Midodrine - Wikipedia

    en.wikipedia.org/wiki/Midodrine

    Midodrine, also known as 3,6-dimethoxy-β-hydroxy-N-aminoethanonyl-2-phenylethylamine, is a substituted phenethylamine derivative. [4] Midodrine is an odorless, white, crystalline powder, soluble in water and sparingly soluble in methanol. [19] Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.

  4. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    Medications delivered to the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many medications than that of the oral route. Rectal mucosa is highly vascularized tissue that allows for rapid and effective absorption of medications. [15]

  5. Macy catheter - Wikipedia

    en.wikipedia.org/wiki/Macy_Catheter

    The Macy Catheter is a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal route. The catheter was developed to make rectal access more practical and provide a way to deliver and retain liquid formulations in the distal rectum so that health practitioners can leverage the established benefits of rectal administration.

  6. Hepatorenal syndrome - Wikipedia

    en.wikipedia.org/wiki/Hepatorenal_syndrome

    [1] [2] [29] However, one study of 13 patients with hepatorenal syndrome showed significant improvement in kidney function when the two were used together (with midodrine given orally, octreotide given subcutaneously and both dosed according to blood pressure), with three patients surviving to discharge. [30]

  7. ...First Do No Harm - Wikipedia

    en.wikipedia.org/wiki/...First_Do_No_Harm

    The parents fear he may become a "vegetable" and are losing hope. At one point, Robbie goes into status epilepticus (a continuous convulsive seizure that must be stopped as a medical emergency). Increasing doses of diazepam (Valium) are given intravenously to no effect. Eventually, paraldehyde is given rectally. This drug is described as having ...

  8. Pharmacokinetics of estradiol - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics_of_estradiol

    Trough estradiol levels and MADRS Tooltip Montgomery–Åsberg Depression Rating Scale scores with 1 mg sublingual micronized estradiol 3 to 8 times per day (3 to 8 mg/day total; mean 4.8 mg/day total) in women with postpartum depression. Blood was drawn specifically in the mornings before the first dose of sublingual estradiol for the day.

  9. Fecalith - Wikipedia

    en.wikipedia.org/wiki/Fecalith

    It can form secondary to fecal impaction. A fecaloma is a more severe form of fecal impaction, and a hardened fecaloma may be considered a giant fecalith. The term is from the Greek líthos =stone.

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