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Pyruvate from glycolysis is converted by fermentation to lactate using the enzyme lactate dehydrogenase and the coenzyme NADH in lactate fermentation, or to acetaldehyde (with the enzyme pyruvate decarboxylase) and then to ethanol in alcoholic fermentation. [citation needed] Pyruvate is a key intersection in the network of metabolic pathways.
The FDA approved mitapivat based on evidence from two clinical trials of 107 participants with pyruvate kinase deficiency. [3] Trial 1 (NCT03548220) of 80 adults with pyruvate kinase deficiency who did not receive regular blood transfusions and trial 2 (NCT03559699) of 27 adults with pyruvate kinase deficiency who received regular blood transfusions. [3]
Earle's balanced salt solution is an isotonic saline solution (or balanced salt solution) formulated by W.R. Earle in 1943. [1] It contains sodium chloride, potassium chloride, calcium chloride, magnesium sulfate, sodium dihydrogen phosphate, sodium bicarbonate and dextrose (glucose).
Minimal essential medium (MEM) is a synthetic cell culture medium developed by Harry Eagle first published in 1959 in Science that can be used to maintain cells in tissue culture. [1] It is based on six salts and glucose described in Earle's salts in 1934: calcium chloride , potassium chloride , magnesium sulfate , sodium chloride , sodium ...
Sodium pyruvate is a salt of the conjugate anion form of pyruvic acid, known as pyruvate. It is commonly added to cell culture media as an additional source of energy, but may also have protective effects against hydrogen peroxide. This was reported by Giandomenico et al. [1] and has been confirmed by several independent groups.
SSRIs are a type of antidepressant often used for PTSD. These medications work by optimizing serotonin — colloquially referred to as the “feel-good chemical” — activity in the brain.
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
In the photo, Johnson was also joined by wife Kelley Phleger. The two share three children: 24-year-old Grace, 22-year-old Jasper and 18-year-old Deacon Johnson.