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Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. [1] Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and increased risk of infection. [1]
The goals of therapy are to control symptoms, improve quality of life, improve overall survival, and decrease progression to AML. The IPSS scoring system can help guide therapy for patients with MDS. [ 43 ] [ 44 ] In those with low risk MDS (designated by an IPSS score less than 3.5), no disease specific treatment has been found to be helpful ...
A 2006 follow-up of 553 patients using imatinib (Gleevec) found an overall survival rate of 89% after five years. [33] A 2011 followup of 832 patients using imatinib who achieved a stable cytogenetic response found an overall survival rate of 95.2% after 8 years, which is similar to the rate in the general population.
Life expectancy in the U.S. is projected to increase from 78.3 years in 2022 to 79.9 years in 2035 and to 80.4 years in 2050 for all sexes combined, researchers said.
Tyrosine kinase inhibitors like imatinib have improved the prognosis of CML patients to near-normal life expectancy. [14] Recently, a JAK2 inhibitor, namely ruxolitinib, has been approved for use in primary myelofibrosis. [15] Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms.
Acute erythroid leukemia is rare, accounting for only 3–5% of all acute myeloid leukemia cases. [2] One study estimated an occurrence rate of 0.077 cases per 100,000 people each year. [ 12 ] 64–70% of people with this condition are male, and most are elderly, with a median age of 65.
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