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  2. Ethosuximide - Wikipedia

    en.wikipedia.org/wiki/Ethosuximide

    Ethosuximide, sold under the brand name Zarontin among others, is a medication used to treat absence seizures. [4] It may be used by itself or with other antiseizure medications such as valproic acid. [4] Ethosuximide is taken by mouth. [4] Ethosuximide is usually well tolerated. [5]

  3. Absence seizure - Wikipedia

    en.wikipedia.org/wiki/Absence_seizure

    Although ethosuximide is effective in treating only absence seizures, valproic acid is effective in treating multiple seizure types including tonic-clonic seizure and partial seizure, suggesting it is a better choice if a patient is exhibiting multiple types of seizures. [25]

  4. Childhood absence epilepsy - Wikipedia

    en.wikipedia.org/wiki/Childhood_absence_epilepsy

    The pathophysiology of absence seizures has been linked to oscillatory thalamic-cortical potentials, calcium currents, and the interaction of GABAergic neurons. It seems clear that the pathophysiology of absence seizures differs from other epilepsies which may, in part, explain the unique efficacy of ethosuximide in this syndrome.

  5. Anticonvulsant - Wikipedia

    en.wikipedia.org/wiki/Anticonvulsant

    Therefore, almost all new epilepsy drugs are initially approved only as adjunctive (add-on) therapies. Patients whose epilepsy is uncontrolled by their medication (i.e., it is refractory to treatment) are selected to see if supplementing the medication with the new drug leads to an improvement in seizure control.

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  7. Great Pyrenees Dog Completely Misses the Obvious When it ...

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    So I understand the hesitation of the dog in this video, who wants to walk through the door the way he’s used to it opening. It’s still super funny, though. View the original article to see ...

  8. Neurologists reveal 15 subtle migraine symptoms — that aren't ...

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    A migraine attack can be a debilitating condition. But a headache is just one part. There are other subtle warning symptoms to watch out for, neurologists say.

  9. T-type calcium channel - Wikipedia

    en.wikipedia.org/wiki/T-type_calcium_channel

    The first-line treatments for childhood absence epilepsy, valproate and ethosuximide, are both blockers of T-type calcium channels; the second-line treatment, lamotrigine, although not a T-type calcium channel blocker, does inhibit high-voltage activated calcium channels. [9]

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