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A 25 mg/mL concentration of progesterone oil for intramuscular injection and a 38 mg/device progesterone intrauterine device (Progestasert) have been discontinued. [ 93 ] An oral combination formulation of micronized progesterone and estradiol in oil-filled capsules (brand name Bijuva) is marketed in the United States for the treatment of ...
EC/MPA is available in the form of a microcrystalline aqueous suspension of 5 mg EC and 25 mg MPA given in a 0.5 mL aqueous solution for intramuscular injection once per month. [10] It is provided in the form of single-dose vials and ampoules. [10] The particle sizes of the formulation are 93% within a range of 5 to 16 μm. [11]
Progestogens that have been studied for potential use as POICs but were never marketed as such include the progesterone derivatives algestone acetophenide (dihydroxyprogesterone acetophenide) (100 mg/month), chlormadinone acetate (250 mg/3 months), hydroxyprogesterone caproate (250–500 mg/month), gestonorone caproate (2.5–200 mg/1–2 ...
Estradiol benzoate is and has been available as an oil solution for intramuscular injection provided as vials and ampoules at concentrations of 0.167, 0.2, 0.33, 1, 1.67, 2, 5, 10, 20, and 25 mg/mL. [ 23 ] [ 31 ] [ 8 ] It is also available as a microcrystalline aqueous suspension for intramuscular injection under the brand name Agofollin Depot.
Hydroxyprogesterone caproate (Delalutin, Makena, Makena Preservative Free) – 125 mg/mL, 250 mg/mL; Medroxyprogesterone acetate (Depo-Provera) – 400 mg/mL – approved specifically for the treatment of endometrial/renal cancer; Progesterone (Progesterone) – 50 mg/mL (25 mg/mL discontinued)
Estradiol valerate/hydroxyprogesterone caproate (EV/OHPC), sold under the brand names Gravibinon and Injectable No. 1 (or Chinese Injectable No. 1) among others, is a combined estrogen and progestogen medication which is used in the treatment of threatened miscarriage and other indications (e.g., as a means of pseudopregnancy) [1] [2] [3] and as a form of combined injectable birth control to ...
[64] [65] It has also been marketed in the form of 100, 200, 250, 400, and 500 mg oral tablets; 500 and 1,000 mg oral suspensions; and as a 50 mg/mL microcrystalline aqueous suspension for intramuscular injection. [66] [67] A 100 mg/mL microcrystalline aqueous suspension for intramuscular injection was previously available as well. [64]
A single intramuscular injection of estradiol valerate/norethisterone enanthate (5 mg/50 mg) (Mesigyna) has been found to strongly suppress testosterone levels in men. [33] Testosterone levels decreased from a baseline of ~503 ng/dL to a trough of ~30 ng/dL (a 94% decrease) which occurred at day 7 post-injection. [33]
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