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The proof of concept of BOLD-contrast imaging was provided by Seiji Ogawa and Colleagues in 1990, following an experiment which demonstrated that an in vivo change of blood oxygenation could be detected with MRI. [6] In Ogawa's experiments, blood-oxygenation-level–dependent imaging of rodent brain slice contrast in different components of the ...
By contrast, a bold font weight makes letters of a text thicker than the surrounding text. [2] Bold strongly stands out from regular text, and is often used to highlight keywords important to the text's content. For example, printed dictionaries often use boldface for their keywords, and the names of entries can conventionally be marked in bold ...
In some literature articles, the terms "mechanism of action" and "mode of action" are used interchangeably, typically referring to the way in which the drug interacts and produces a medical effect. However, in actuality, a mode of action describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living ...
A mechanism of action of a chemical could be "binding to DNA" while its broader mode of action would be "transcriptional regulation". [3] However, there is no clear consensus and the term mode of action is also often used, especially in the study of pesticides, to describe molecular mechanisms such as action on specific nuclear receptors or ...
Contrast is the antonym of simile. In poetic compositions, it is common for poets to set out an elaborate contrast or elaborate simile as the argument. For example, John Donne and the metaphysical poets developed the conceit as a literary device, where an
In 1968, Norman Holland drew on psychoanalytic psychology in The Dynamics of Literary Criticism to model the literary work. [11] Each reader introjects a fantasy "in" the text, then modifies it by defense mechanisms into an interpretation. In 1973, however, having recorded responses from real readers, Holland found variations too great to fit ...
Peter Selgin refers to methods, including action, dialogue, thoughts, summary, scene, and description. While dialogue is the element that brings a story and its characters to life on the page, and narrative gives the story its depth and substance, action creates the movement within a story.
Literary movements are a way to divide literature into categories of similar philosophical, topical, or aesthetic features, as opposed to divisions by genre or period. Like other categorizations, literary movements provide language for comparing and discussing literary works. These terms are helpful for curricula or anthologies. [1]