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Neom (styled NEOM; Arabic: نيوم, romanized: Niyōm, Hejazi Arabic pronunciation: [nɪˈjo̞ːm]) is an urban area being built by Saudi Arabia in Tabuk Province.Launched in 2017 by crown prince Mohammad bin Salman, the site is at the northern tip of the Red Sea, due east of Egypt across the Gulf of Aqaba and south of Jordan.
The cell cycle hypothesis of AD proposes that the disease is caused by aberrant re-entry of different neuronal populations into the cell division cycle, following a 2-hit hypothesis (Nagy et al. 1998). The cell cycle hypothesis of AD also attempts to explain for the characteristic senile plaques and the neurofibrillary tangles of AD pathology.
In eukaryotes, the cell cycle consists of four main stages: G 1, during which a cell is metabolically active and continuously grows; S phase, during which DNA replication takes place; G 2, during which cell growth continues and the cell synthesizes various proteins in preparation for division; and the M phase, during which the duplicated ...
After DNA damage, cell cycle checkpoints are activated. Checkpoint activation pauses the cell cycle and gives the cell time to repair the damage before continuing to divide. DNA damage checkpoints occur at the G1/S and G2/M boundaries. An intra-S checkpoint also exists. Checkpoint activation is controlled by two master kinases, ATM and ATR.
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Overview of signal transduction pathways involved in apoptosis. Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as diseases, localized injury, or the death of the organism of which the cells are part.
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Steps of the cell cycle. The G 2-M checkpoint occurs between the G 2 and M phases. G2-M arrest. The G 2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired.