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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
Complex Post-Traumatic Stress Disorder (CPTSD) Complex PTSD is a form of PTSD that can develop in people who experience ongoing or long-term trauma or multiple traumas. This may include ...
Cyproheptadine, a non-selective serotonin receptor antagonist (including of the serotonin 5-HT 2A receptor), is used as an antidote in the treatment of serotonin syndrome (or serotonin toxicity) caused by serotonergic drugs, including the toxicity of serotonergic psychedelics like the NBOMe drugs.
Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [8] [9] [6] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
Psychotherapy is an effective treatment for trauma-related disorders. A meta-analysis of treatment outcomes has shown that 67% of patients who completed treatment for PTSD no longer met diagnostic criteria for PTSD. [4] For those seeking evidence-based psychotherapy treatment, it is estimated that 22-24% will drop out of their treatment.
In June, the FDA's Psychopharmacologic Drugs Advisory Committeevoted 9-2 against MDMA as an effective treatment for PTSD patients, and 10-1 that the drug's benefits do not outweigh the risks.
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