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Luteal support is the administration of medication, generally progesterone, progestins, hCG or GnRH agonists, to increase the success rate of implantation and early embryogenesis, thereby complementing and/or supporting the function of the corpus luteum. It can be combined with for example in vitro fertilization and ovulation induction.
The levels of hCG in the body increase rapidly in the first few weeks of pregnancy, doubling every 48–72 hours. [7] The highest level of hCG is reached in week 10 or week 11, later the levels of hCG can be used to estimate the age of the fetus and monitor the progress of the pregnancy. [6]
Progesterone has noticeable effects on respiratory physiology, increasing minute volume (the amount of air breathed in and out of the lungs in 1 minute) by 40% in the first trimester via an increase in tidal volume alone, as the respiratory rate does not change during pregnancy. [44] [45] As a result, carbon dioxide levels in the blood decrease ...
Estrogen, progesterone, and human chorionic gonadotropin (hCG) levels throughout pregnancy. Estrogen, progesterone, and 17α-hydroxyprogesterone (17α-OHP) levels during pregnancy in women. [ 1 ] The dashed vertical lines separate the trimesters .
Certain progestogens are used to support pregnancy, including progesterone, hydroxyprogesterone caproate, dydrogesterone, and allylestrenol. They are used questionably for treatment of recurrent pregnancy loss and for prevention of preterm birth in pregnant women with a history of at least one spontaneous preterm birth. [42]
Levels of progesterone during pregnancy are up to 100-fold higher than during normal menstrual cycling, although levels increase gradually over the course of pregnancy. [135] Oral dosages of progesterone of as high as 3,600 mg/day have been assessed in clinical trials, with the main side effect being sedation. [ 136 ]
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