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Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. [3] [10] NTDs include anencephaly and spina bifida, among other defects.
Minnich et al. dosed mongrel dogs subcutaneously with aminopterin and folic acid simultaneously to test whether folic acid can rescue animals from the lethality and toxicity of aminopterin [24] Dogs were given 0.020, 0.046, 0.044 escalated to 0.088, and 0.097 mg/kg aminopterin each day for 7 to 12 days. Folic acid was given in a weight ratio to ...
Folic acid, which is the synthetic form of the vitamin folate, is critical both in pre- and peri-conception. [7] Deficiencies in folic acid may cause neural tube defects (NTDs). Women who had 0.4 mg of folic acid in their systems due to supplementing 3 months before childbirth significantly reduced the risk of NTDs. [ 29 ]
Treatment may include dietary changes and folic acid supplements. [1] Dietary changes including eating foods high in folate such as, fruits and green leafy vegetables can help. [1] Prevention is recommended for pregnant women or those who are planning a pregnancy. [1] Folate deficiency is very rare in countries with folic acid fortification ...
Doses of folic acid over 1 mg are prescription only. The amount of non-prescription prenatal vitamins needed to achieve this dose may have too much vitamin A and lead to fetal toxicity. [2] In addition, the U.S Army currently provides female soldiers with optional prenatal supplements to combat high anemia rates in female soldiers. [10]
One study in 184 premature infants, reported that individuals given monthly vitamin B 12 injections (100 μg) or taking supplements of vitamin B 12 and folic acid (100 μg/day), had higher haemoglobin concentrations after 10–12 weeks, compared to those only taking folic acid or those taking no vitamin B 12 injections. [87]
Abscessed dermoid sinuses will be at best a recurrent, painful problem, and if the sinus communicates with the tissues around the spinal cord, cause meningitis and often death. However, it has been shown that supplementation of folic acid to the diet of the brood bitch before mating and during pregnancy reduces the incidence of dermoid sinus. [28]
[42] [39] Vitamin B 12 is not one of the supplements recommended by the World Health Organization for healthy women who are pregnant, [10] however, vitamin B 12 is often suggested during pregnancy in a multivitamin along with folic acid [43] [44] especially for pregnant mothers who follow a vegetarian or vegan diet. [45]
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