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Anaphylaxis is a severe allergic reaction of rapid onset affecting many body systems. [5] [8] It is due to the release of inflammatory mediators and cytokines from mast cells and basophils, typically due to an immunologic reaction but sometimes non-immunologic mechanism. [8]
Mast cells serve the same general functions in the body and central nervous system, such as effecting or regulating allergic responses, innate and adaptive immunity, autoimmunity, and inflammation. [4] [17] Across systems, mast cells serve as the main effector cell through which pathogens can affect the gut–brain axis. [18] [19]
The immune system will produce immunoglobulin E, IgE, antibodies for each allergen. The antibodies will cause cells in the body to produce histamine. This histamine will act on different areas of the body (eyes, throat, nose, gastrointestinal tract, skin or lungs) to produce symptoms of an allergic reaction.
“Histamine is released in the body and enters the gastrointestinal tract, which can cause gas, bloating, nausea, stomach pains and diarrhea.” He notes specific foods that can make seasonal ...
The products of the early phase reaction include chemokines and molecules that act on endothelial cells and cause them to express Intercellular adhesion molecule (such as vascular cell adhesion molecule and selectins), which together result in the recruitment and activation of leukocytes from the blood into the site of the allergic reaction. [3]
Histamine, the structure shown, causes a person to feel itchy during an allergic reaction. Conditions caused by food allergies are classified into three groups according to the mechanism of the allergic response: [56] IgE-mediated (classic) – the most common type, occurs shortly after eating and may involve anaphylaxis.
A man with a life-threatening milk allergy has sued McDonald’s alleging that a slice of American cheese on his Big Mac caused him to have a severe allergic reaction.
In some people, dermatitis is the result of simple irritation, but for others, it could signal an allergic reaction. This particular side effect is more common with the 5% concentration of the drug.