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Pernicious anemia was a fatal disease before about the year 1920; until the importance of the liver in hematopoiesis was recognized, the treatment of pernicious anemia was unsuccessful and arbitrary. It may have motivated George Whipple , who had a keen interest in liver diseases , to investigate the liver's role in hematopoiesis.
Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [2] [8] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Pernicious anemia: D51.0: 9870: Pernicious anemia (also known as macrocytic achylic anemia, congenital pernicious anemia, juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B 12.
Anemia can be temporary or long term and can range from mild to severe. [6] Anemia can be caused by blood loss, decreased red blood cell production, and increased red blood cell breakdown. [1] Causes of blood loss include bleeding due to inflammation of the stomach or intestines, bleeding from surgery, serious injury, or blood donation. [1]
A deficiency of cobalt, which is very rare, is also potentially lethal, leading to pernicious anemia. [1] Exposure to cobalt metal dust is most common in the fabrication of tungsten carbide. [2] Another source is from wear and tear of certain metal-on-metal hip prostheses. [3]
For those with pernicious anemia, vitamin B12 supplements are recommended either by mouth or by injection. [3] People are usually advised to avoid foods that bother them. [10] Gastritis is believed to affect about half of people worldwide. [4] In 2013 there were approximately 90 million new cases of the condition. [11]
Doctor checking patient for anemia symptoms While often associated with iron, anemia can also stem from not getting enough protein in your diet. According to the NIH , hemoglobin, crucial for ...
Autoimmune disease. Thymoma. [2] Viral infections such as HIV, herpes, parvovirus B19 (Fifth disease), [3] or hepatitis. [citation needed] Lymphoproliferative. Association of pure red cell aplasia with T-cell large granular lymphocyte leukemia is well recognized, especially in China. [4] Idiopathic. Many cases of PRCA are considered idiopathic ...
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