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For example, when the blood pressure drug felodipine is taken with grapefruit juice rather than water, levels of the medication in the blood can more than double and result in headache, irregular ...
Grapefruit–drug interactions that affect the pre-systemic metabolism (i.e., the metabolism that occurs before the drug enters the blood) of drugs have a different duration of action than interactions that work by other mechanisms, such as on absorption, discussed below.
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (especially grapefruit) and other juices with medications is advised against.
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health.
Important: If you're taking statins or medications for conditions like high blood pressure, cholesterol, heart arrhythmia, organ transplants, or allergies, it can be dangerous to eat grapefruit ...
The Grapefruit-drug interaction article lists Levothyroxine as one of the drugs whose absorption is affected by grapefruit, but the only readily available research online, which is the one cited, ([1]), concluded that "Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its ...
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health. Grapefruit can interfere with certain medications