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The free fraction in synovial fluid is 2.5 times higher than in plasma, due to the lower albumin content in synovial fluid compared to plasma. The significance of this penetration is unknown, [ 28 ] but it may account for the fact that it performs exceptionally well in treatment of arthritis in animal models.
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Prey animals, sheep, goats, pigs and cattle, were progressively domesticated early in the history of agriculture. [3] Pigs were domesticated in the Near East between 8,500 and 8000 BC, [4] sheep and goats in or near the Fertile Crescent about 8,500 BC, [5] and cattle from wild aurochs in the areas of modern Turkey and Pakistan around 8,500 BC. [6]
Researchers have examined animal cognition in mammals (especially primates, cetaceans, elephants, bears, dogs, cats, pigs, horses, [2] [3] [4] cattle, raccoons and rodents), birds (including parrots, fowl, corvids and pigeons), reptiles (lizards, snakes, and turtles), [5] fish and invertebrates (including cephalopods, spiders and insects).
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