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Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash , joint pain , fever , and lymphadenopathy .
True serum sickness, a type III hypersensitivity reaction, results in fever, lymphadenopathy, arthralgias, cutaneous eruptions, gastrointestinal disturbances, proteinuria, and significant decreases in serum complement levels; it was originally described after patients were infused with equine immunoglobulins.
In immunology, the Arthus reaction (/ ˌ ɑːr ˈ tj uː s /) is a type of local type III hypersensitivity reaction.Type III hypersensitivity reactions are immune complex-mediated, and involve the deposition of antigen/antibody complexes mainly in the vascular walls, serosa (pleura, pericardium, synovium), and glomeruli.
The most common diseases involving a type III hypersensitivity reaction are serum sickness, post-streptococcal glomerulonephritis, systemic lupus erythematosus, farmers' lung (hypersensitivity pneumonitis), and rheumatoid arthritis.
Serum sickness: A hypersensitivity. Spondyloarthropathy: No consistent evidence of association with autoimmunity. Sweet's syndrome: No consistent evidence of association with autoimmunity. Takayasu's arteritis: No consistent evidence of association with autoimmunity. Undifferentiated spondyloarthropathy
Ways to avoid heater sickness. If you want to reduce your risk of getting heater sickness, experts recommend the following: Choose the right filters.
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Antivenoms are purified from animal serum by several processes and may contain other serum proteins that can act as immunogens.Some individuals may react to the antivenom with an immediate hypersensitivity reaction (anaphylaxis) or a delayed hypersensitivity (serum sickness) reaction, and antivenom should, therefore, be used with caution.